![]() 10 Leukodystrophies are genetic rare diseases that affect the central nervous system by disrupting myelination. One study described symptoms and MRI findings of MOG antibody disease in children under the age of 7 that were similar to leukodystrophies. 1 NMDA receptor encephalitis is an autoimmune encephalitis that can cause psychosis, issues with memory and language, and seizures. MOG antibody disease can also occur in relation to another condition called anti-N-methyl-D-aspartate (NMDA) receptor encephalitis. When a relapse occurs, the diagnosis of MOGAD is confirmed. In some, the MOG antibody persists, and relapses may occur. In many kids, the MOG antibody disappears within 1 year, and relapses do not occur. 4Ĭhildren can be found to have the MOG antibody in the setting of ADEM however, a positive MOG antibody test in the setting of ADEM does not necessarily imply a course of MOGAD. Those with MOG antibody disease are more likely to have both optic nerves affected at the same time, and if the symptoms are in only one eye, the other optic nerve may show subclinical atrophy. Paraparesis (weakness) of a limb or limbs.Paralysis (no motor function) of a limb or limbs.Loss or blurring of vision in one or both eyes.MOG antibody disease preferentially causes inflammation in the optic nerve, 8 but can also cause inflammation in the spinal cord, brain, and brainstem. COVID-19 and Rare Neuroimmune Disorders.
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